Eukaryotic translation initiation factor 4E binding protein 1 (4EBP-1) function is suppressed by Src and PP2A on extracellular matrix
نویسندگان
چکیده
Richard Seonghun Nho* and Mark Peterson Running title : Integrin-collagen interaction suppresses 4EBP-1 function Present address: Department of Medicine, University of Minnesota, 420 Delaware Street, SE, Minneapolis, Minnesota 55455 Address of corresponding author: Richard Seonghun Nho, Box 276, University of Minnesota, 420 Delaware Street SE., Minneapolis, Minnesota, 55455 Telephone: 612-625-0686, Fax: 612-625-2174, email: [email protected]
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4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression
West Nile virus (WNV) is a (+) sense, single-stranded RNA virus in the Flavivirus genus. WNV RNA possesses an m7GpppNm 5' cap with 2'-O-methylation that mimics host mRNAs preventing innate immune detection and allowing the virus to translate its RNA genome through the utilization of cap-dependent translation initiation effectors in a wide variety of host species. Our prior work established the ...
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Stem cell factor (SCF)–induced activation of phosphoinositide-3-kinase (PI3K) is required for transient amplification of the erythroblast compartment. PI3K stimulates the activation of mTOR (target of rapamycin) and subsequent release of the cap-binding translation initiation factor 4E (eIF4E) from the 4E-binding protein 4EBP, which controls the recruitment of structured mRNAs to polysomes. Enh...
متن کاملIgbp1 is part of a positive feed-back loop in SCF-dependent, selective mRNA translation initiation inhibiting erythroid differentiation
Stem cell factor (SCF)-induced activation of phosphoinositide-3-kinase (PI3K) is required for transient amplification of the erythroblast compartment. PI3K stimulates the activation of mTOR (Target of Rapamycin) and subsequent release of the cap-binding translation initiation factor 4E (eIF4E) from the 4E-binding protein 4EBP, which controls the recruitment of structured mRNAs to polysomes. Enh...
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